Dr. Hoon has coauthored more than 170 peer-reviewed articles primarily related to translational molecular oncology pertaining to solid tumors. He is the founder and Director of the Department of Molecular Oncology, where he is investigating novel molecular/genetic biomarkers for diagnosis of minimal residual tumor disease, and as prognostic/predictive biomarkers during solid tumor progression. Focus has been in the assessment of molecular genetic biomarkers as well as functional genomic changes in both cancer patients tissues and body fluids. Emphasis is in molecular staging and classification of human solid tumors. The group is also developing and preclinically testing molecular therapeutics of RNA/DNA polyvalent cancer-gene vaccines. The department is funded by the National Institutes of Health, the California Breast Cancer Research program, the United States Department of Defense (Prostate Cancer), and Pharmobiotechs. Dr. Hoon has served on several review study sections for the National Cancer Institute and the National Institute of Health. Under Dr. Hoon’s direction the department consists of 22 MD/PhD and research technicians focused on translation molecular oncology. He has trained more than 50 surgical/medical oncology and Ph.D. postdoctoral fellows, who now hold faculty appointments in numerous academic institutions. Education
- B.Sc. (Functional Biology), U. of Victoria, Canada. 1977
- M.Sc. (Viral Tumor Pathology), University of Manitoba, Dept. Pathology, Health Science Center, Canada. 1979.
- Ph.D. (Tumor Metastasis and Immunology), University of Saskatchewan, Dept. Microbiology and Immunology, Health Science Center, Canada. 1983.
- Postdoctoral/Research Associate Faculty Series, University of California, Los Angeles, School of Medicine, Dept of Surgery, Division Surgical Oncology. 1983-1987.
- Assistant Professor, University of California, Los Angeles, School of Medicine – Department of Surgery, Division Surgical Oncology, 1988-1991.Associate Member, JWCI, Director Dept. Molecular Immunology, Santa Monica, CA.
Research Interest
Developing and validating molecular/genetic biomarkers for human solid tumors in identifying clinical utility for diagnosis, prognosis, and prediction. Analysis of tumor-related genomic aberrations in tissues and blood. Molecular upstaging of sentinel lymph nodes in solid tumors. Developing novel molecular therapeutic approaches using gene vaccines. Identification of molecular targets for chemoprevention.
Pub Med Publications
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